[Analysis of the clinical features of infections caused by enterovirus A71 (EV-A71) in Balearic Islands].
نویسندگان
چکیده
Los enterovirus constituyen un amplio grupo de virus de distribución ambiental. Afectan preferentemente a la población infantil con enfermedades respiratorias, gastrointestinales, cuadros exantemáticos, febriles y neurológicos. Se trasmiten fácilmente de persona a persona por la vía fecal-oral y presentan un período de incubación de 1-3 días1. Dentro de los más de 100 enterovirus conocidos, el enterovirus 71 (EV-A71) pertenece al género A, que incluye más de 25 serotipos distintos, entre los cuales está el Coxsackievirus A16 causante de la enfermedad mano-pieboca (EMPB)1,2. El EV-A71 se describió por primera vez en brotes de infección neurológica entre 1969-1972. A partir de este momento se ha detectado en todo el mundo de una forma más o menos prevalente1. En general se le considera causante de cuadros respiratorios leves o moderados, de la EMPB y de cuadros neurológicos de gravedad variable (meningitis, encefalitis o parálisis flácida)1,2. En algunos casos de EMPB los pacientes presentan una encefalitis localizada a nivel del tronco que se denomina romboencefalitis y que puede dejar graves secuelas neurológicas1,2. Tras el brote de epidémico de infección neurológica causado por el EV-A71 en Cataluña3, nos ha parecido interesante analizar las características clínicas de los pacientes infectados por este virus en Baleares. Durante el período comprendido entre mayo de 2015 y junio de 2016 se ha estudiado la presencia de enterovirus en las muestras respiratorias (frotis faríngeos) de pacientes pediátricos con sospecha clínica de infección respiratoria
منابع مشابه
Enterovirus A71 Meningoencephalitis Outbreak, Rostov-on-Don, Russia, 2013
Seventy-eight cases of enterovirus infection, including 25 neuroinfections, occurred in Rostov-on-Don, Russia, during May-June 2013. The outbreak was caused by an enterovirus A type 71 (EV-A71) subgenotype C4 lineage that spread to neighboring countries from China ≈3 years earlier. Enterovirus associated neuroinfection may emerge in areas with a preceding background circulation of EV-A71 with a...
متن کاملImpact of genetic changes, pathogenicity and antigenicity on Enterovirus- A71 vaccine development.
Enterovirus-A71 (EV-A71) is an etiological agent of the hand, foot and mouth disease (HFMD). EV-A71 infection produces high fever and ulcers in children. Some EV-A71 strains produce severe infections leading to pulmonary edema and death. Although the protective efficacy of the inactivated vaccine (IV) was ≥90% against mild HFMD, there was approximately 80% protection against severe HFMD. The mo...
متن کاملNew Introductions of Enterovirus 71 Subgenogroup C4 Strains, France, 2012
In France during 2012, human enterovirus 71 (EV-A71) subgenogroup C4 strains were detected in 4 children hospitalized for neonatal fever or meningitis. Phylogenetic analysis showed novel and independent EV-A71 introductions, presumably from China, and suggested circulation of C4 strains throughout France. This observation emphasizes the need for monitoring EV-A71 infections in Europe.
متن کاملA clinically authentic mouse model of enterovirus 71 (EV-A71)-induced neurogenic pulmonary oedema
Enterovirus 71 (EV-A71) is a neurotropic virus that sporadically causes fatal neurologic illness among infected children. Animal models of EV-A71 infection exist, but they do not recapitulate in animals the spectrum of disease and pathology observed in fatal human cases. Specifically, neurogenic pulmonary oedema (NPE)-the main cause of EV-A71 infection-related mortality-is not observed in any o...
متن کاملHand, Foot, and Mouth Disease in China: Modeling Epidemic Dynamics of Enterovirus Serotypes and Implications for Vaccination
BACKGROUND Hand, foot, and mouth disease (HFMD) is a common childhood illness caused by serotypes of the Enterovirus A species in the genus Enterovirus of the Picornaviridae family. The disease has had a substantial burden throughout East and Southeast Asia over the past 15 y. China reported 9 million cases of HFMD between 2008 and 2013, with the two serotypes Enterovirus A71 (EV-A71) and Coxsa...
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ورودعنوان ژورنال:
- Anales de pediatria
دوره 87 5 شماره
صفحات -
تاریخ انتشار 2017